Discovery and structure-activity relationship studies of N-substituted indole derivatives as novel Mcl-1 inhibitors

Luan, SL; Ge, Q; Chen, YD; Dai, MY; Yang, JY; Li, K; Liu, D; Zhao, LX

Liu, D; Zhao, LX (reprint author), Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drugs Design & Discovery, Shenyang 110016, Peoples R China.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017; 27 (9): 1943

Abstract

Myeloid cell leukemia-1 (Mcl-1) is an important antiapoptotic protein functioning through protein-protein interactions. We discovered LSL-A6 (24((2-ca......

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