Design, synthesis, structure-activity relationship studies, and evaluation of novel GLS1 inhibitors

Jo, M; Koizumi, K; Suzuki, M; Kanayama, D; Watanabe, Y; Gouda, H; Mori, H; Mizuguchi, M; Obita, T; Nabeshima, Y; Toyooka, N; Okada, T

Koizumi, K (通讯作者)，Univ Toyama, Inst Nat Med, Div Presymptomat Dis, Toyama 9300194, Japan.;Okada, T (通讯作者)，Univ Toyama, Grad Sch Sci & Engn, Toyama 9308555, Japan.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023; 87 ():

Abstract

Glutaminase converts glutamine into glutamic acid and has two isoforms: glutaminase 1 (GLS1) and glutaminase 2 (GLS2). GLS1 is overexpressed in severa......

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