Multivalent Small-Molecule Pan-RAS Inhibitors

Welsch, ME; Kaplan, A; Chambers, JM; Stokes, ME; Bos, PH; Zask, A; Zhang, Y; Sanchez-Martin, M; Badgley, MA; Huang, CS; Tran, TH; Akkiraju, H; Brown, LM; Nandakumar, R; Cremers, S; Yang, WS; Tong, L; Olive, KP; Ferrando, A; Stockwell, BR

Stockwell, BR (reprint author), Columbia Univ, Dept Chem, New York, NY 10027 USA.

CELL, 2017; 168 (5): 878

Abstract

Design of small molecules that disrupt protein-protein interactions, including the interaction of RAS proteins and their effectors, may provide chemic......

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