The Tarantula Toxin omega-Avsp1a Specifically Inhibits Human Ca(V)3.1 and Ca(V)3.3 via the Extracellular S3-S4 Loop of the Domain 1 Voltage-Sensor

Herzig, V; Chen, YC; Chin, YKY; Dekan, Z; Chang, YW; Yu, HM; Alewood, PF; Chen, CC; King, GF

Herzig, V; King, GF (通讯作者),Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia.;Herzig, V (通讯作者),Univ Sunshine Coast, Ctr Bioinnovat, Sippy Downs, Qld 4556, Australia.;Herzig, V (通讯作者),Univ Sunshine Coast, Sch Sci Technol & Engn, Sippy Downs, Qld 4556, Australia.;Chen, CC (通讯作者),Acad Sinica, Inst Biomed Sci, Taipei 11529, Taiwan.;King, GF (通讯作者),Univ Queensland, Australian Res Council Ctr Excellence Innovat Pep, St Lucia, Qld 4072, Australia.

BIOMEDICINES, 2022; 10 (5):

Abstract

Inhibition of T-type calcium channels (Ca(V)3) prevents development of diseases related to cardiovascular and nerve systems. Further, knockout animal ......

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