PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling

Lin, YF; Yang, J; Yang, QL; Zeng, S; Zhang, JY; Zhu, YX; Tong, YX; Li, L; Tan, WQ; Chen, DH; Sun, QM

Sun, QM (通讯作者)，Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Jia 3 Datun Rd, Beijing 100101, Peoples R China.;Chen, DH (通讯作者)，Yunnan Univ, Inst Biomed Res, Kunming 650500, Peoples R China.;Sun, QM (通讯作者)，Chinese Acad Sci, Inst Stem Cells & Regenerat, Beijing 100101, Peoples R China.;Sun, QM (通讯作者)，Beijing Inst Stem Cell & Regenerat Med, Beijing 100101, Peoples R China.;Sun, QM (通讯作者)，Univ Chinese Acad Sci, Sch Life Sci, Beijing 100049, Peoples R China.

NATURE COMMUNICATIONS, 2023; 14 (1):

Abstract

TANK-binding kinase 1 (TBK1) is a key kinase in regulating antiviral innate immune responses. While the oligomerization of TBK1 is critical for its fu......

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