Enhanced uptake of blood coagulation factor VIII containing immune complexes by antigen presenting cells

Hartholt, RB; Wroblewska, A; Herczenik, E; Peyron, I; Ten Brinke, A; Rispens, T; Nolte, MA; Slot, E; Claassens, JW; Nimmerjahn, F; Verbeek, JS; Voorberg, J

Voorberg, J (reprint author), Sanquin Res, Dept Plasma Prot, Plesmanlaan 125, NL-1066 CX Amsterdam, Netherlands.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2017; 15 (2): 329

Abstract

Background: A major complication in the treatment of hemophilia A is the development of inhibitory antibodies targeting coagulation factor VIII (FVIII......

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