SIRT1 modulates cell cycle progression by regulating CHK2 acetylation-phosphorylation

Zhang, WY; Feng, YL; Guo, QQ; Guo, WD; Xu, HD; Li, XM; Yi, F; Guan, Y; Geng, NX; Wang, PY; Cao, LY; O'Rourke, BP; Jo, J; Kwon, J; Wang, RH; Song, XY; Lee, I; Cao, L

Song, XY; Cao, L (corresponding author), China Med Univ, Inst Translat Med, Key Lab Cell Biol, Minist Publ Hlth, 77 Puhe Rd, Shenyang 110122, Liaoning, Peoples R China.; Song, XY; Cao, L (corresponding author), China Med Univ, Key Lab Med Cell Biol, Minist Educ, Liaoning Prov Collaborat Innovat Ctr Aging Relate, 77 Puhe Rd, Shenyang 110122, Liaoning, Peoples R China.; Lee, I (corresponding author), Ewha Womans Univ, Dept Life Sci, Coll Nat Sci, Off 106,Sci Bldg C,52 Ewhayeodae Gil, Seoul 03760, South Korea.

CELL DEATH AND DIFFERENTIATION, 2020; 27 (2): 482

Abstract

Both the stress-response protein, SIRT1, and the cell cycle checkpoint kinase, CHK2, play critical roles in aging and cancer via the modulation of cel......

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