Novel 1,4-benzothazines obliterate COX-2 mediated JAK-2/STAT-3 signals with potential regulation of oxidative and metabolic stress during colorectal cancer

Rai, A; Kumar, U; Raj, V; Singh, AK; Kumar, P; Keshari, AK; Kumar, D; Maity, B; De, A; Samanta, A; Nath, S; Prakash, A; Gosipatala, SB; Chand, G; Saha, S

Saha, S (reprint author), Babasaheb Bhimrao Ambedkar Univ, Dept Pharmaceut Sci, Raebareli Rd, Lucknow 226025, Uttar Pradesh, India.

PHARMACOLOGICAL RESEARCH, 2018; 132 (): 188

Abstract

1,4-benzothiazines have ameliorative effects through inhibition of COX-2 mediated STAT-3 pathways at G-protein couple receptor site. As per this scena......

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