A Small Molecule Inhibitor, OGP46, Is Effective against Imatinib-Resistant BCR-ABL Mutations via the BCR-ABL/JAK-STAT Pathway

Wei, LY; Yang, Y; Gupta, P; Wang, AH; Zhao, M; Zhao, Y; Qu, M; Ke, Y; Liu, Y; Liu, HM; Xu, X; Sun, YL; Chen, ZS; Hu, ZB

Hu, ZB (corresponding author), Weifang Med Univ, Lab Stem Cell & Regenerat Med, Affiliated Hosp, 288 Shengli East St, Weifang 261042, Shandong, Peoples R China.; Chen, ZS (corresponding author), St Johns Univ, Dept Pharmaceut Sci, Coll Pharm & Hlth Sci, 8000 Utopia Pkwy, Queens, NY 11439 USA.

MOLECULAR THERAPY-ONCOLYTICS, 2020; 18 (): 137

Abstract

Chronic myeloid leukemia (CML) is caused by the Philadelphia (Ph+) chromosome carrying the BCR-ABL oncogene, a constitutively active tyrosine kinase. ......

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