Genetic determinants of VWF clearance and FVIII binding modify FVIII pharmacokinetics in pediatric hemophilia A patients

Swystun, LL; Ogiwara, K; Rawley, O; Brown, C; Georgescu, I; Hopman, W; Labarque, V; Male, C; Thom, K; Blanchette, VS; Carcao, MD; Lillicrap, D

Lillicrap, D (reprint author), Queens Univ, Richardson Lab, 88 Stuart St, Kingston, ON K7L 3N6, Canada.

BLOOD, 2019; 134 (11): 880

Abstract

Factor VIII (FVIII) pharmacokinetic (PK) properties show high interpatient variability in hemophilia A patients. Although previous studies have determ......

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