Oligonucleotide-based pharmaceuticals: Non-clinical and clinical safety signals and non-clinical testing strategies

Mustonen, EK; Palomaki, T; Pasanen, M

Pasanen, M (reprint author), Univ Eastern Finland, Fac Hlth Sci, Sch Pharm, POB 1627, Kuopio 70211, Finland.

REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2017; 90 ( ): 328

Abstract

Antisense oligonucleotides, short interfering RNAs (siRNAs) and aptamers are oligonucleotide-based pharmaceuticals with a promising role in targeted t......

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