Effective Depletion of Pre-existing Anti-AAV Antibodies Requires Broad Immune Targeting

Velazquez, VM; Meadows, AS; Pineda, RJ; Camboni, M; McCarty, DM; Fu, HY

Fu, HY (reprint author), Nationwide Childrens Hosp, Res Inst, Ctr Gene Therapy, Columbus, OH 43205 USA.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2017; 4 ( ): 159

Abstract

Pre-existing antibodies (Abs) to AAV pose a critical challenge for the translation of gene therapies. No effective approach is available to overcome p......

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