Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic

Reddy, JA; Dorton, R; Bloomfield, A; Nelson, M; Dircksen, C; Vetzel, M; Kleindl, P; Santhapuram, H; Vlahov, IR; Leamon, CP

Leamon, CP (reprint author), Endocyte Inc, 3000 Kent Ave,Suite A1-100, W Lafayette, IN 47906 USA.

SCIENTIFIC REPORTS, 2018; 8 ():

Abstract

EC1456 is a folate-tubulysin conjugate constructed with an all-D enantiomeric spacer/linker configuration. When tested against folate receptor (FR)-po......

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