Specific properties of shRNA-mediated CCR5 downregulation that enhance the inhibition of HIV-1 infection in combination with shRNA targeting HIV-1 rev

Cardona, ME; Hinkula, J; Gustafsson, K; Christensson, B; Wahren, B; Mohamed, AJ; Smith, CIE; Arteaga, HJ

Hinkula, J (通讯作者)，Linkoping Univ, Dept Biomed & Clin Sci, Linkoping, Sweden.

MOLECULAR BIOLOGY REPORTS, 2022; 49 (11): 11187

Abstract

Treatment with RNAi against HIV-1 transcripts efficiently inhibits viral replication but induces selection of escape mutants; therefore, the CCR5 core......

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