The nicotine-degrading enzyme NicA2 reduces nicotine levels in blood, nicotine distribution to brain, and nicotine discrimination and reinforcement in rats

Pentel, PR; Raleigh, MD; LeSage, MG; Thisted, T; Horrigan, S; Biesova, Z; Kalnik, MW

Raleigh, MD (reprint author), Minneapolis Med Res Fdn Inc, 701 Pk Ave, Minneapolis, MN 55415 USA.

BMC BIOTECHNOLOGY, 2018; 18 ():

Abstract

Background: The bacterial nicotine-degrading enzyme NicA2 isolated from P. putida was studied to assess its potential use in the treatment of tobacco ......

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