Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates

Liu, B; Dong, XL; Zheng, CW; Keener, D; Chen, ZX; Cheng, HY; Watts, JK; Xue, W; Sontheimer, EJ

Xue, W; Sontheimer, EJ (通讯作者)，Univ Massachusetts, RNA Therapeut Inst, Chan Med Sch, Worcester, MA 01655 USA.;Xue, W; Sontheimer, EJ (通讯作者)，Univ Massachusetts, Li Weibo Inst Rare Dis Res, Chan Med Sch, Worcester, MA 01655 USA.;Sontheimer, EJ (通讯作者)，Univ Massachusetts, Chan Med Sch, Dept Biochem & Mol Biotechnol, Worcester, MA 01655 USA.;Xue, W (通讯作者)，Univ Massachusetts, Chan Med Sch, Dept Mol Cell & Canc Biol, Worcester, MA 01655 USA.;Xue, W; Sontheimer, EJ (通讯作者)，Univ Massachusetts, Chan Med Sch, Dept Mol Med, Worcester, MA 01655 USA.

NATURE BIOTECHNOLOGY, 2023; ():

Abstract

Reverse transcriptases, used in prime editing systems, exhibit lower fidelity, processivity and dNTP affinity than many DNA-dependent DNA polymerases.......

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