Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy

Faisal, A; Mak, GWY; Gurden, MD; Xavier, CPR; Anderhub, SJ; Innocenti, P; Westwood, IM; Naud, S; Hayes, A; Box, G; Valenti, MR; Brandon, AKD; O'Fee, L; Schmitt, J; Woodward, HL; Burke, R; vanMontfort, RLM; Blagg, J; Raynaud, FI; Eccles, SA; Hoelder,

Linardopoulos, S (reprint author), Canc Res UK, Canc Therapeut Unit, Div Canc Therapeut, Inst Canc Res, London, England.; Linardopoulos, S (reprint author), Inst Canc Res, Div Breast Canc Res, Breast Canc Now, London, England.

BRITISH JOURNAL OF CANCER, 2017; 116 (9): 1166

Abstract

Background: The main role of the cell cycle is to enable error-free DNA replication, chromosome segregation and cytokinesis. One of the best character......

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