From the Cover: Fenretinide, Troglitazone, and Elmiron Add to Weight of Evidence Support for Hemangiosarcoma Mode-of-Action From Studies in Mice

Cook, JC; Obert, LA; Koza-Taylor, P; Coskran, TM; Opsahl, AC; Ziemek, D; Roy, M; Qian, J; Lawton, MP; Criswell, KA

Cook, JC (reprint author), Pfizer, Drug Safety Res & Dev, Pfizer Worldwide Res & Dev, Eastern Point Rd,MS 8274-1222, Groton, CT 06340 USA.

TOXICOLOGICAL SCIENCES, 2018; 161 (1): 58

Abstract

Pharmaceuticals and chemicals produce hemangiosarcomas (HS) in mice, often by nongenotoxic, proliferative mechanisms. A mode-of-action (MOA) for heman......

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