Thrombospondin-1 proteomimetic polymers exhibit anti-angiogenic activity in a neovascular age-related macular degeneration mouse model

Choi, W; Nensel, AK; Droho, S; Fattah, MA; Mokashi-Punekar, S; Swygart, DI; Burton, ST; Schwartz, GW; Lavine, JA; Gianneschi, NC

Gianneschi, NC (通讯作者)，Northwestern Univ, Int Inst Nanotechnol, Dept Chem, Evanston, IL 60208 USA.;Schwartz, GW; Lavine, JA (通讯作者)，Northwestern Univ, Dept Ophthalmol, Feinberg Sch Med, Chicago, IL 60611 USA.;Schwartz, GW (通讯作者)，Northwestern Univ, Weinberg Sch Arts & Sci, Dept Neurosci, Chicago, IL 60611 USA.;Gianneschi, NC (通讯作者)，Northwestern Univ, Simpson Querrey Inst, Dept Mat Sci & Engn Biomed Engn Pharmacol, Chem Life Proc Inst,Lurie Canc Ctr, Evanston, IL 60208 USA.

SCIENCE ADVANCES, 2023; 9 (41):

Abstract

Neovascular age-related macular degeneration (nAMD) is the leading cause of blindness in the developed world. Current therapy includes monthly intraoc......

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