Discovery of Acyl-sulfonamide Na(v)1.7 Inhibitors GDC-0276 and GDC-0310

Safina, BS; McKerrall, SJ; Sun, SY; Chen, CA; Chowdhury, S; Jia, Q; Li, J; Zenova, AY; Andrez, JC; Bankar, G; Bergeron, P; Chang, JH; Chang, E; Chen, J; Dean, R; Decker, SM; DiPasquale, A; Focken, T; Hemeon, I; Khakh, K; Kim, A; Kwan, R; Lindgren, A; Lin, S; Maher, J; Mezeyova, J; Misner, D; Nelkenbrecher, K; Pang, J; Reese, R; Shields, SD; Sojo, L; Sheng, T; Verschoof, H; Waldbrook, M; Wilson, MS; Xie, ZW; Young, C; Zabka, TS; Hackos, DH; Ortwine, DF; White, AD; Johnson, JP; Robinette, CL; Dehnhardt, CM; Cohen, CJ; Sutherlin, DP

McKerrall, SJ; Sutherlin, DP (corresponding author), Genentech Inc, San Francisco, CA 94080 USA.

JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (6): 2953

Abstract

Na(v)1.7 is an extensively investigated target for pain with a strong genetic link in humans, yet in spite of this effort, it remains challenging to i......

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