Purification of HCC-specific extracellular vesicles on nanosubstrates for early HCC detection by digital scoring

Sun, N; Lee, YT; Zhang, RY; Kao, RH; Teng, PC; Yang, YY; Yang, P; Wang, JJ; Smalley, M; Chen, PJ; Kim, M; Chou, SJ; Bao, LR; Wang, J; Zhang, XY; Qi, DP; Palomique, J; Nissen, N; Han, SHB; Sadeghi, S; Finn, RS; Saab, S; Busuttil, RW; Markovic, D; Elashoff, D; Yu, HH; Li, HY; Heaney, AP; Posadas, E; You, S; Yang, JD; Pei, RJ; Agopian, VG; Tseng, HR; Zhu, YZ

Tseng, HR; Zhu, YZ (corresponding author), Univ Calif Los Angeles, Calif NanoSyst Inst, Crump Inst Mol Imaging, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA.; Pei, RJ (corresponding author), Chinese Acad Sci, Key Lab Nanobio Interface, Suzhou Inst Nanotech & Nanobion, Univ Chinese Acad Sci, Suzhou 215123, Peoples R China.; Agopian, VG (corresponding author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Surg, Los Angeles, CA 90095 USA.; Agopian, VG; Tseng, HR (corresponding author), Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA.

NATURE COMMUNICATIONS, 2020; 11 (1):

Abstract

We report a covalent chemistry-based hepatocellular carcinoma (HCC)-specific extracellular vesicle (EV) purification system for early detection of HCC......

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