NMR-directed design of pre-TCR beta and pMHC molecules implies a distinct geometry for pre-TCR relative to alpha beta TCR recognition of pMHC

Mallis, RJ; Arthanari, H; Lang, MJ; Reinherz, EL; Wagner, G

Wagner, G (reprint author), Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA.

JOURNAL OF BIOLOGICAL CHEMISTRY, 2018; 293 (3): 754

Abstract

The pre-T cell receptor (pre-TCR) guides early thymocytes through maturation processes within the thymus via interaction with self-ligands displayed o......

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