Molecular modeling study of the thymidine phosphorylase inhibitor by SBDD and classical QSAR analysis

Tada, Y; Kazuno, H; Sato, T; Suzuki, N; Emura, T; Yano, S

Tada, Y (reprint author), Tokyo Inst Technol, Dept Computat Intelligence & Syst Sci, Minato Ku, 3-3-6 Shibaura, Tokyo 1080023, Japan.

CHEM-BIO INFORMATICS JOURNAL, 2017; 17 ( ): 19

Abstract

Trifluorothymidine (TFT) has antitumor activity, but it is easily metabolized to inert trifluorothymine by thymidine phosphorylase (TP). Accordingly, ......

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