Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta

Campbell, MG; Cormier, A; Ito, S; Seed, RI; Bondesson, AJ; Lou, J; Marks, JD; Baron, JL; Cheng, YF; Nishimura, SL

Cheng, YF (corresponding author), Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA.; Nishimura, SL (corresponding author), Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USA.; Cheng, YF (corresponding author), Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA.

CELL, 2020; 180 (3): 490

Abstract

Integrin alpha v beta 8 binds with exquisite specificity to latent transforming growth factor-beta (L-TGF-beta). This binding is essential for activat......

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