Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model

Wu, H; Huang, Q; Qi, ZP; Chen, YF; Wang, AL; Chen, C; Liang, QM; Wang, JH; Chen, WS; Dong, J; Yu, KL; Hu, C; Wang, WC; Liu, XC; Deng, YX; Wang, L; Wang, BL; Li, XX; Gray, NS; Liu, J; Wei, W; Liu, QS

Liu, J; Liu, QS (reprint author), Chinese Acad Sci, High Magnet Field Lab, Mailbox 1110,350 Shushanhu Rd, Hefei 230031, Anhui, Peoples R China.; Liu, QS (reprint author), Univ Sci & Technol China, Hefei 230036, Anhui, Peoples R China.; Wei, W (reprint aut

SCIENTIFIC REPORTS, 2017; 7 ( ):

Abstract

BTK plays a critical role in the B cell receptor mediated inflammatory signaling in the rheumatoid arthritis ( RA). Through a rational design approach......

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