The Design, Synthesis and Preliminary Pharmacokinetic Evaluation of d3-Poziotinib Hydrochloride

Ma, SC; Wang, LA; Ouyang, B; Bai, XF; Ji, QL; Yao, L

Yao, L (reprint author), Yantai Univ, Sch Pharm, Yantai 264005, Shandong, Peoples R China.; Ji, QL; Yao, L (reprint author), Shandong Luye Pharma Grp, Yantai 264003, Shandong, Peoples R China.

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2019; 42 (6): 873

Abstract

To establish a synthetic route to d3-poziotinib hydrochloride. Treatment of 4-chloro-7-hydroxyquinazolin-6-yl pivalate (1) with d3-methyliodide afford......

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