Necrostatin-1 Attenuates Renal Ischemia and Reperfusion Injury via Meditation of HIF-1 alpha/mir-26a/TRPC6/PARP1 Signaling

Shen, BB; Mei, M; Pu, YM; Zhang, HH; Liu, H; Tang, MZ; Pan, QG; He, Y; Wu, XF; Zhao, HW

Zhao, HW (reprint author), Army Med Univ, Affiliated Hosp 1, Dept Kidney, 30 Gaotanyan Zhengjie, Chongqing 400038, Peoples R China.; Wu, XF (reprint author), Wuhan Univ, Eastern Hosp, Renmin Hosp, Dept Nephrol, 17 High Tech 6th Rd, Wuhan 430200, Hubei, Pe

MOLECULAR THERAPY-NUCLEIC ACIDS, 2019; 17 (): 701

Abstract

Necroptosis, oxidative stress, and inflammation are major contributors to the pathogenesis of ischemic acute kidney injury. Necrostatin-1 (Nec-1), an ......

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