Advanced Glycation End Product Inhibitor Pyridoxamine Attenuates IVD Degeneration in Type 2 Diabetic Rats

Glaeser, JD; Ju, D; Tawackoli, W; Yang, JH; Salehi, K; Stefanovic, T; Kanim, LEA; Avalos, P; Kaneda, G; Stephan, S; Metzger, MF; Bae, HW; Sheyn, D

Sheyn, D (corresponding author), Cedars Sinai Med Ctr, Orthopaed Stem Cell Res Lab, Los Angeles, CA 90048 USA.; Sheyn, D (corresponding author), Cedars Sinai Med Ctr, Board Governors Regenerat Med Inst, Los Angeles, CA 90048 USA.; Sheyn, D (corresponding author), Cedars Sinai Med Ctr, Dept Orthoped, Los Angeles, CA 90048 USA.; Sheyn, D (corresponding author), Cedars Sinai Med Ctr, Dept Surg, Los Angeles, CA 90048 USA.; Sheyn, D (corresponding author), Cedars Sinai Med Ctr, Dept Biomed Sci, Los Angeles, CA 90048 USA.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020; 21 (24):

Abstract

Type 2 diabetes mellitus (T2DM) is associated with advanced glycation end product (AGE) enrichment and considered a risk factor for intervertebral dis......

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