Resistance to RET-Inhibition in RET-Rearranged NSCLC Is Mediated By Reactivation of RAS/MAPK Signaling

Nelson-Taylor, SK; Le, AT; Yoo, M; Schubert, L; Mishall, KM; Doak, A; Varella-Garcia, M; Tan, AC; Doebele, RC

Doebele, RC (reprint author), Univ Colorado, Sch Med, 12801 E 17th Ave, Aurora, CO 80045 USA.

MOLECULAR CANCER THERAPEUTICS, 2017; 16 (8): 1623

Abstract

Oncogenic rearrangements in RET are present in 1%-2% of lung adenocarcinoma patients. Ponatinib is a multi-kinase inhibitor with low-nanomolar potency......

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