TRAF2 and TRAF5 associated with the signal transducing receptor gp130 limit IL-6-driven transphosphorylation of JAK1 through the inhibition of proximal JAK-JAK interaction

Kimura, M; Nagashima, H; Okuyama, Y; Ishii, N; So, T

So, T (reprint author), Tohoku Univ, Dept Microbiol & Immunol, Grad Sch Med, Aoba Ku, 2-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan.; So, T (reprint author), Univ Toyama, Grad Sch Med & Pharmaceut Sci, Lab Mol Cell Biol, 2630 Sugitani, Toyama 9300194, J

INTERNATIONAL IMMUNOLOGY, 2018; 30 (7): 291

Abstract

Tumor necrosis factor receptor-associated factor 2 (TRAF2) and TRAF5 constitutively bind to glycoprotein 130 kDa (gp130) and inhibit IL-6-driven activ......

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