Elucidation of an Allosteric Mode of Action for a Thienopyrazole ROR gamma t Inverse Agonist

de Vries, RMJM; Doveston, RG; Meijer, FA; Brunsveld, L

Brunsveld, L (corresponding author), Eindhoven Univ Technol, Dept Biomed Engn, Den Dolech 2, NL-5612 AZ Eindhoven, Netherlands.; Brunsveld, L (corresponding author), Eindhoven Univ Technol, Inst Complex Mol Syst, Den Dolech 2, NL-5612 AZ Eindhoven, Netherlands.

CHEMMEDCHEM, 2020; 15 (7): 561

Abstract

The demand for allosteric targeting of nuclear receptors is high, but examples are limited, and structural information is scarce. The retinoic acid-re......

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