Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA

Morimoto, S; Tsuda, M; Bunch, H; Sasanuma, H; Austin, C; Takeda, S

Takeda, S (reprint author), Kyoto Univ, Grad Sch Med, Dept Radiat Genet, Sakyo Ku, Kyoto 6068501, Japan.

GENES, 2019; 10 (11):

Abstract

Type II DNA topoisomerase enzymes (TOP2) catalyze topological changes by strand passage reactions. They involve passing one intact double stranded DNA......

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