Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis

Lu, XY; Shi, XJ; Hu, AO; Wang, JQ; Ding, Y; Jiang, W; Sun, M; Zhao, XL; Luo, J; Qi, W; Song, BL

Song, BL (corresponding author), Wuhan Univ, Inst Adv Studies, Frontier Sci Ctr Immunol & Metab, Hubei Key Lab Cell Homeostasis,Coll Life Sci, Wuhan, Peoples R China.

NATURE, 2020; 588 (7838): 479

Abstract

Cholesterol is an essential lipid and its synthesis is nutritionally and energetically costly(1,2). In mammals, cholesterol biosynthesis increases aft......

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