Targeting SPHK1/S1PR3-regulated S-1-P metabolic disorder triggers autophagic cell death in pulmonary lymphangiomyomatosis (LAM)

Li, F; Zhang, YF; Lin, ZJ; Yan, LZ; Liu, Q; Li, Y; Pei, XL; Feng, Y; Han, X; Yang, J; Zheng, FX; Li, TJ; Zhang, YP; Fu, ZK; Shao, D; Yu, JE; Li, CG

Li, CG (通讯作者)，Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300350, Peoples R China.;Li, CG (通讯作者)，Nankai Univ, Coll Pharm, Tianjin 300350, Peoples R China.;Shao, D (通讯作者)，Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Chongqing 400000, Peoples R China.;Shao, D (通讯作者)，Chonggang Gen Hosp, Chongqing 400000, Peoples R China.;Yu, JE (通讯作者)，Univ Cincinnati, Dept Internal Med, Div Pulm Crit Care & Sleep Med, Coll Med, Cincinnati, OH 45267 USA.

CELL DEATH & DISEASE, 2022; 13 (12):

Abstract

Lymphangioleiomyomatosis (LAM), a progressive pulmonary disease exclusively affecting females, is caused by defects or mutations in the coding gene tu......

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