Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor

Caravella, JA; Lin, J; Diebold, RB; Campbell, AM; Ericsson, A; Gustafson, G; Wang, ZG; Castro, J; Clarke, A; Gotur, D; Josephine, HR; Katz, M; Kershaw, M; Yao, LL; Toms, AV; Barr, KJ; Dinsmore, CJ; Walker, D; Ashwell, S; Lu, W

Caravella, JA; Lin, J (corresponding author), FORMA Therapeut Inc, Watertown, MA 02472 USA.; Campbell, AM (corresponding author), FORMA Therapeut Inc, Branford, CT 06405 USA.

JOURNAL OF MEDICINAL CHEMISTRY, 2020; 63 (4): 1612

Abstract

Inhibition of mutant IDH1 is being evaluated clinically as a treatment option for oncology. Here we describe the structure-based design and optimizati......

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