Systematic discovery of natural CRISPR-Cas12a inhibitors

Watters, KE; Fellmann, C; Bai, HB; Ren, SM; Doudna, JA

Doudna, JA (reprint author), Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA.; Doudna, JA (reprint author), Gladstone Inst, San Francisco, CA 94158 USA.; Doudna, JA (reprint author), Univ Calif Berkeley, Dept Chem, Berk

SCIENCE, 2018; 362 (6411): 236

Abstract

Cas12a (Cpf1) is a CRISPR-associated nuclease with broad utility for synthetic genome engineering, agricultural genomics, and biomedical applications.......

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