Heterogenous loss of mismatch repair (MMR) protein expression: a challenge for immunohistochemical interpretation and microsatellite instability (MSI) evaluation

McCarthy, AJ; Capo-Chichi, JM; Spence, T; Grenier, S; Stockley, T; Kamel-Reid, S; Serra, S; Sabatini, P; Chetty, R

Chetty, R (reprint author), Univ Hlth Network, Toronto Gen Hosp, Lab Med Program, Dept Anat Pathol, 200 Elizabeth St,11th Floor,Eaton Wing, Toronto, ON MSG 2C4, Canada.

JOURNAL OF PATHOLOGY CLINICAL RESEARCH, 2019; 5 (2): 115

Abstract

Immunohistochemistry (IHC) for mismatch repair (MMR) proteins is used to identify MMR status: being diffusely positive (intact/retained nuclear staini......

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