Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein

Oyen, D; Torres, JL; Aoto, PC; Flores-Garcia, Y; Binter, S; Pholcharee, T; Carroll, S; Reponen, S; Wash, R; Liang, Q; King, CR; Emerling, D; Kellam, P; Zavala, F; Ward, AB; Wilson, IA; Lemiale, F; Locke, E; Bradley, A

Wilson, IA (corresponding author), Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA.; Wilson, IA (corresponding author), Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA.

PLOS PATHOGENS, 2020; 16 (3):

Abstract

Lasting protection has long been a goal for malaria vaccines. The major surface antigen on Plasmodium falciparum sporozoites, the circumsporozoite pro......

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