Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice

Leiter, O; Brici, D; Fletcher, SJ; Yong, XLH; Widagdo, J; Matigian, N; Schroer, AB; Bieri, G; Blackmore, DG; Bartlett, PF; Anggono, V; Villeda, SA; Walker, TL

Walker, TL (通讯作者)，Univ Queensland, Queensland Brain Inst, Clem Jones Ctr Ageing Dementia Res, Brisbane, Qld 4072, Australia.

NATURE COMMUNICATIONS, 2023; 14 (1):

Abstract

Exercise has positive effects on the brain during aging. Here the authors show that in mice, platelet-released exerkine PF4 mediates the effects of ex......

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