Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core

Liosi, ME; Krimmer, SG; Newton, AS; Dawson, TK; Puleo, DE; Cutrona, KJ; Suzuki, Y; Schlessinger, J; Jorgensen, WL

Jorgensen, WL (corresponding author), Yale Univ, Dept Chem, New Haven, CT 06520 USA.

JOURNAL OF MEDICINAL CHEMISTRY, 2020; 63 (10): 5324

Abstract

Janus kinases (JAKs) are non-receptor tyrosine kinases that are essential components of the JAK-STAT signaling pathway. Associated aberrant signaling ......

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