Mutation in MCL1 predicted loop to helix structural transition stabilizes MCL1-Bax binding interaction favoring cancer cell survival

Shyl, ENSGD; Malgija, B; Iniyan, AM; Vincent, SGP

Malgija, B (通讯作者)，Madras Christian Coll, Computat Sci Lab, MCC MRF Innovat Pk, Chennai 600059, Tamil Nadu, India.;Vincent, SGP (通讯作者)，Manonmaniam Sundaranar Univ, Int Ctr Nanobiotechnol ICN, Ctr Marine Sci & Technol CMST, Rajakkamangalam 629502, Tamil Nadu, India.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2022; 90 (9): 1699

Abstract

Myeloid cell leukemia-1 (MCL1), an anti-apoptotic BCL-2 family protein plays a major role in the control of apoptosis as the regulator of mitochondria......

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