The novel peptide athycaltide-1 attenuates Ang II-induced pathological myocardial hypertrophy by reducing ROS and inhibiting the activation of CaMKII and ERK1/2

Zheng, X; Su, FX; Lei, M; Li, JY; Zhang, CY; Zhang, YJ; Wei, M; Li, W; Chen, SC; Liu, YZ; Gao, QH; Hao, LY

Gao, QH; Hao, LY (通讯作者),China Med Univ, Sch Pharm, Dept Pharmaceut Toxicol, 77 Puhe Rd, Shenyang 110122, Peoples R China.;Gao, QH (通讯作者),China Med Univ, Dept Dev Cell Biol, Key Lab Med Cell Biol, Key Lab Cell Biol,Minist Publ Hlth,Minist Educ, 77 Puhe Rd, Shenyang 110122, Peoples R China.

EUROPEAN JOURNAL OF PHARMACOLOGY, 2023; 957 ():

Abstract

Pathological myocardial hypertrophy initially develops as an adaptive response to cardiac stress, which can be induced by many diseases. It is accompa......

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