Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity

Jia, N; Mo, CY; Wang, CY; Eng, ET; Marraffini, LA; Patel, DJ

Jia, N; Patel, DJ (reprint author), Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10065 USA.; Jia, N; Patel, DJ (reprint author), Southern Univ Sci & Technol, Shenzhen 518055, Guangdong, Peoples R China.

MOLECULAR CELL, 2019; 73 (2): 264

Abstract

Type III CRISPR-Cas systems provide robust immunity against foreign RNA and DNA by sequence-specific RNase and target RNA-activated sequence-nonspecif......

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