CD19-CAR-T Cells Bearing a KIR/PD-1-Based Inhibitory CAR Eradicate CD19(+)HLA-C1(-) Malignant B Cells While Sparing CD19(+)HLA-C1(+) Healthy B Cells

Tao, L; Farooq, MA; Gao, YX; Zhang, L; Niu, CY; Ajmal, I; Zhou, Y; He, C; Zhao, GX; Yao, J; Liu, MY; Jiang, WZ

Jiang, WZ (corresponding author), East China Normal Univ, Sch Life Sci, Shanghai Key Lab Regulatory Biol, Shanghai 200241, Peoples R China.

CANCERS, 2020; 12 (9):

Abstract

Simple Summary CD19-targeted chimeric antigen receptor (CAR) T (CD19-CAR-T) cell therapy usually causes B cell aplasia because of "on-target off-tumor......

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