[225Ac]Ac- and [111In]In-DOTA-trastuzumab theranostic pair: cellular dosimetry and cytotoxicity in vitro and tumour and normal tissue uptake in vivo in NRG mice with HER2-positive human breast cancer xenografts

Kondo, M; Cai, ZL; Chan, CR; Forkan, N; Reilly, RM

Reilly, RM (通讯作者)，Univ Toronto, Leslie Dan Fac Pharm, Dept Pharmaceut Sci, Toronto, ON M5S 3M2, Canada.;Reilly, RM (通讯作者)，Princess Margaret Canc Ctr, Toronto, ON, Canada.;Reilly, RM (通讯作者)，Univ Toronto, Dept Med Imaging, Toronto, ON, Canada.;Reilly, RM (通讯作者)，Univ Hlth Network, Joint Dept Med Imaging, Toronto, ON, Canada.

EJNMMI RADIOPHARMACY AND CHEMISTRY, 2023; 8 (1):

Abstract

Background: Trastuzumab (Herceptin) has improved the outcome for patients with HER2-positive breast cancer (BC) but brain metastases (BM) remain a cha......

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