PI3K-AKT-mTOR pathway alterations in advanced NSCLC patients after progression on EGFR-TKI and clinical response to EGFR-TKI plus everolimus combination therapy

Fang, WF; Huang, YH; Gu, WG; Gan, JD; Wang, WJ; Zhang, SY; Wang, K; Zhan, JH; Yang, YP; Huang, Y; Zhao, HY; Zhang, L

Fang, WF; Zhang, L (corresponding author), Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Dept Med Oncol, State Key Lab Oncol South China,Canc Ctr, Guangzhou 510060, Peoples R China.

TRANSLATIONAL LUNG CANCER RESEARCH, 2020; 9 (4): 1258

Abstract

Background: Several mechanisms including abnormal activation of PI3K-AKT-mTOR pathway have been proved to generate acquired resistance to epidermal gr......

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