Enhanced late sodium current underlies pro-arrhythmic intracellular sodium and calcium dysregulation in murine sodium channelopathy

Rivaud, MR; Baartscheer, A; Verkerk, AO; Beekman, L; Rajamani, S; Belardinelli, L; Bezzina, CR; Remme, CA

Remme, CA (reprint author), Acad Med Ctr, Dept Expt Cardiol, Room K2-104-2,Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands.

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2018; 263 (): 54

Abstract

Background: Long QT syndrome mutations in the SCN5A gene are associated with an enhanced late sodium current (I-Na,I-L) which may lead to pro-arrhythm......

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