Activation of the Aryl Hydrocarbon Receptor Leads to Resistance to EGFR TKIs in Non-Small Cell Lung Cancer by Activating Src-mediated Bypass Signaling

Ye, MX; Zhang, Y; Gao, HJ; Xu, Y; Jing, PY; Wu, JX; Zhang, XX; Xiong, J; Dong, CF; Yao, LB; Zhang, J; Zhang, J

Zhang, J; Zhang, J (reprint author), Fourth Mil Med Univ, Dept Biochem & Mol Biol, State Key Lab Canc Biol, 169 West Changle Rd, Xian 710032, Shaanxi, Peoples R China.; Zhang, J (reprint author), Fourth Mil Med Univ, Xijing Hosp, Dept Pulm Med, 169 West C

CLINICAL CANCER RESEARCH, 2018; 24 (5): 1227

Abstract

Purpose: The aryl hydrocarbon receptor (AhR) has been generally recognized as a ligand-activated transcriptional factor that responds to xenobiotic ch......

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