On the Process of Discovering Leads That Target the Heparin-Binding Site of Neutrophil Elastase in the Sputum of Cystic Fibrosis Patients

Morla, S; Sankaranarayanan, NV; Afosah, DK; Kumar, M; Kummarapurugu, AB; Voynow, JA; Desai, UR

Desai, UR (reprint author), Virginia Commonwealth Univ, Dept Med Chem, Richmond, VA 23298 USA.; Desai, UR (reprint author), Virginia Commonwealth Univ, Inst Struct Biol Drug Discovery & Dev, Richmond, VA 23219 USA.

JOURNAL OF MEDICINAL CHEMISTRY, 2019; 62 (11): 5501

Abstract

Cystic fibrosis (CF) is a disease of dysregulated salt and fluid homeostasis that results in the massive accumulation of neutrophil elastase, resultin......

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