Consolidated BRCA1/2 Variant Interpretation by MH BRCA Correlates with Predicted PARP Inhibitor Efficacy Association by MH Guide

Hirotsu, Y; Schmidt-Edelkraut, U; Nakagomi, H; Sakamoto, I; Hartenfeller, M; Narang, R; Soldatos, TG; Kaduthanam, S; Wang, XY; Hettich, S; Brock, S; Jackson, DB; Omata, M

Hirotsu, Y (corresponding author), Yamanashi Cent Hosp, Genome Anal Ctr, Kofu, Yamanashi 4008506, Japan.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020; 21 (11):

Abstract

BRCA1/2 variants are prognostic biomarkers for hereditary breast and/or ovarian cancer (HBOC) syndrome and predictive biomarkers for PARP inhibition. ......

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